At the Bioanalytical Toxicology group, we investigate the impact of plastics and other synthetic materials on human and ecosystem health. For that we are using state-of-the-art in vitro and in vivo bioassays to characterize the total toxicity of complex samples (e.g., leachates of plastic materials). We also apply non-target high resolution mass spectrometry and effect-directed chemical analysis to identify the compounds causing the observed toxicity. With this approach we aim at contributing to a more holistic understanding human and environmental exposomes. To achieve this, we are working at the interface of mechanistic toxicology, exposure science, analytical chemistry, and environmental health.
Our latest work focuses on
- Determining the drivers of nanoplastic and microplastic toxicity
- Assessing the environmental risks of plastic pollution
- Characterizing the toxicological profile of the chemicals present in and leaching from plastic consumer products
- Identify (unknown) plastic chemicals to better understand the contribution of plastics to the human exposome